Adviezen commissie BOM

Terug naar lijst Medische Oncologie nummer 4, pp. 35-37
sep 2012, jaargang 14

Pemetrexed als onderhoudsbehandeling bij stadium IIIB/IV niet-kleincellig longcarcinoom

Op basis van de twee besproken fase III-studies kan worden geconcludeerd dat onderhoudsbehandeling met pemetrexed, toegepast na inductiebehandeling bij patiƫnten met een nietplanocellulair gemetastaseerd longcarcinoom (stadium IIIB/ IV), de PFS en OS significant en in klinisch relevante mate verlengt.

Referenties

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  2. Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 2009;374(9699):1432-40.
  3. Belani CP, Brodowicz T, Ciuleanu TE, et al. Quality of life in patients with advanced non-small-cell lung cancer given maintenance treatment with pemetrexed versus placebo (H3E-MC-JMEN): results from a randomised, double-blind, phase 3 study. Lancet Oncol 2012;13(3):292-9.
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  6. Paz Ares L, de Marinis F, Dediu M, et al. PARAMOUNT: final overall survival (OS) results of the phase III study of maintenance pemetrexed (pem) plus best supportive care (BSC) versus placebo (plb) plus BSC immediately following induction treatment with pem plus cisplatin (cis) for advanced nonsquamous (NS) non-small cell lung cancer (NSCLC). J Clin Oncol 2012;30(18) (suppl; abstr LBA7507).