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- Auteur
- NVMO-commissie BOM
- Printdatum
- 14-03-2004
- E-pubdatum
- 14-03-2004
- Bron
- Medische Oncologie
Toevoeging van aprepitant aan 5HT3/dexamethason bij hoog emetogene chemotherapie
Op grond van de thans ter beschikking staande resultaten kan worden aanbevolen aprepitant vanaf de eerste kuur hoog emetogene chemotherapie toe te voegen aan een 5HT3- antagonist- plus dexamethasoncombinatie.
Referenties
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- Hesketh PJ, Grunberg SM, Gralla RJ, et al. ‘The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy induced nausea and vomiting: a multinational, randomized, double-blind, placebo controlled trial in patients receiving high-dose cisplatin’. J Clin Oncol 2003;21: 4112-9.
- De Wit R, Herrstedt J, Rapoport B, et al. ‘Addition of the oral NK1 antagonist aprepitant to standard antemetics provided protection against nausea and vomiting during multiple cycles of cisplatin-based chemotherapy’. J Clin Oncol 2003;21:4105-11.
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- Tsukada H, Hirose T, Yokoyama A, et al. ‘Randomised comparison of ondansetron plus dexamethasone with dexamethasone alone for the control of delayed cisplatin-induced emesis’. Eur J Cancer 2001;37:2398-404.
- U.S. Food and Drug Administration. Aprepitant materials for FDA submission. March 6, 2003. Available onlineat: www.fda.gov/ohrms/dockets/ac/cder03.html#GastrointestinalDrugs.
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