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  • Auteur
  • NVMO-commissie BOM
  • Printdatum
  • 14-06-2004
  • E-pubdatum
  • 23-04-2014
  • Bron
  • Medische Oncologie

Trastuzumab bij het mammacarcinoom

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Een combinatie van trastuzumab met een taxoid moet op basis van de aangetoonde hogere effectiviteit als de combinatie van eerste keuze worden beschouwd bij patiënten met een (3+) positieve Her2/neu-receptor in het tumorweefsel.

Referenties

  1. Baselga J et al. ‘Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer’. Semin Oncol 1999;26:78-83. 
  2. Cobleigh MA et al. ‘Multinational study of the efficacy and safety of humanized anti- HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease’. J Clin Oncol 1999;17: 2639-48.
  3. Vogel CL et al. ‘Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer’. J Clin Oncol 2002;20:719-26.
  4. Seidman AD et al. ‘Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification’. J Clin Oncol 2001;19:2587-95.
  5. Burstein HJ et al. ‘Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study’. J Clin Oncol 2003;21:46-53.
  6. Burstein HJ et al. ‘Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer’. J Clin Oncol 2001;19:2722-30.
  7. Esteva FJ et al. ‘Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer’. J Clin Oncol 2002; 20:1800-8
  8. Pegram MD et al. ‘Phase II study of receptor-enhanced chemosensitivity using recombinant humanized antip185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment’. J Clin Oncol 1998;16:2659-71.
  9. Loesch D et al. ‘Phase II multicenter trial of a weekly paclitaxel and carboplatin regimen in patients with advanced breast cancer’. J Clin Oncol 2002;20:3857-64.
  10. Gori S et al. ‘Phase II study of weekly paclitaxel and trastuzumab in anthracycline- and taxane-pretreated patients with HER2- overexpressing metastatic breast cancer’. Br J Cancer 2004;90:36-40.
  11. Tedesco KL et al. ‘Docetaxel combined with trastuzumab is an active regimen in HER-2 3+ overexpressing and fluorescent in situ hybridizationpositive metastatic
    breast cancer: a multiinstitutional phase II trial’. J Clin Oncol 2004;22:1071-7.
  12. Slamon DJ et al. ‘Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2’. N Engl J Med
    2001;15:783-92.
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